SML1602
RQ-00203078
≥98% (HPLC)
别名:
4-(N-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid, 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]-benzoic acid
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所有图片(1)
About This Item
经验公式（希尔记法）:
C21H13ClF6N2O5S
CAS号:
分子量:
554.85
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 25 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
ClC1=CC(C(F)(F)F)=CN=C1N(S(C2=CC=C(C(O)=O)C=C2)(=O)=O)CC3=CC=C(OC(F)(F)F)C=C3
InChI
1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32)
InChI 密鑰
IJGQFZYYEHCCIZ-UHFFFAOYSA-N
生化／生理作用
RQ-00203078 is an orally available potent and selective TRPM8 antagonist that potently reduces cation currents induced by menthol and other TRPM8 agonists. RQ-00203078 inhibits HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro.
RQ-00203078 is an orally available potent and selective TRPM8 antagonist.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Alec R Nickolls et al.
Cell reports, 30(3), 932-946 (2020-01-23)
Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by overexpressing NGN2 and BRN3A, human pluripotent stem cells can be transcriptionally
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