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Merck

SML1044

Sigma-Aldrich

佐奎达 盐酸盐

≥98% (HPLC), powder, p-Glycoprotein inhibitor

别名:

LY-335979, RS-33295-198, (2R)-抗-5- [3- [4-(10,11-二氟亚甲基二苯并亚苄基-5-基)哌嗪-1-基] -2-羟基丙氧基]喹啉 盐酸盐

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About This Item

经验公式(希尔记法):
C32H31F2N3O2 · xHCl
分子量:
527.60 (free base basis)
分類程式碼代碼:
12161501
PubChem物質ID:
NACRES:
NA.77

product name

佐奎达 盐酸盐, ≥98% (HPLC)

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 4 mg/mL, clear (warmed)

儲存溫度

−20°C

SMILES 字串

O[C@@H](COC1=C(C=CC=N2)C2=CC=C1)CN(CC3)CCN3[C@@H]4C5=C(C=CC=C5)[C@@H]6[C@@H](C6(F)F)C7=C4C=CC=C7.Cl

InChI

1S/C32H31F2N3O2.ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;/h1-14,21,29-31,38H,15-20H2;1H/t21-,29-,30+,31-;/m1./s1

InChI 密鑰

VQJFFWJUYDGTQZ-FCNWNIDBSA-N

生化/生理作用

Zosuqidar是一种P-糖蛋白(P-gp,MDR1)的有效抑制剂,P-糖蛋白是一种转运蛋白,是细胞药物外排的一种关键调节剂。 Zosuquidar可使AML和其他癌细胞系对细胞毒性药物敏感。

特點和優勢

该化合物是ADME Tox研究推荐产品。点击此处 ,查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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