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化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
2-8°C
InChI
1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChI 密鑰
UJJUKZPBUMCSJZ-BQYQJAHWSA-N
應用
PFK15，一种 PFKFB3 抑制剂，已用于研究其对横纹肌肉瘤（RD）细胞自噬和增殖的调节作用。
生化／生理作用
PFK15 也称为 1-（4-吡啶基）-3-（2-喹啉基）-2-丙烯-1-酮。它可以防止横纹肌肉瘤的细胞自噬和繁殖。PFK15 通过线粒体途径导致胃癌细胞死亡。它还在体内阻断 MKN45（人胃癌细胞系）肿瘤的生长。PFK15 促进细胞周期停滞，并改变关键细胞周期蛋白的上调。
PFK15 是 PFKB3（6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶 3）的高效和选择性拮抗剂，可导致癌细胞和转化的细胞快速凋亡。PFK15 抑制 LLC 异种移植物的生长。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
PFK15, a small molecule inhibitor of PFKFB3, induces cell cycle arrest, apoptosis and inhibits invasion in gastric cancer.
Zhu W, et al.
PLoS ONE, 11(9), e0163768-e0163768 (2016)
PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells.
Wang C, et al.
International Journal of Molecular Medicine, 42(1), 359-367 (2018)
Siyuan Yan et al.
Oncotarget, 8(46), 80909-80922 (2017-11-09)
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), is a critical enzyme for glycolysis and highly expressed in cancer cells. It plays an essential role in regulating metabolism, angiogenesis, and inflammation. Although PFKFB3 is involved in modulating autophagy, its regulatory role appears to be
Lingyan Jiang et al.
Nature communications, 12(1), 879-879 (2021-02-11)
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on serine synthesis are mediated by
Q Lu et al.
Cell death & disease, 6, e2005-e2005 (2015-12-04)
Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In
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