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About This Item
经验公式（希尔记法）:
C39H60N10O8 · xC2HF3O2
CAS号:
分子量:
796.96 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
運輸包裝
wet ice
儲存溫度
−20°C
InChI
1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2,41,52)(H,45,55)(H,46,54)(H,47,56)(H,48,57)(H,49,53)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1
InChI 密鑰
KMSCNWHRNILNRJ-JNRWAQIZSA-N
Amino Acid Sequence
Phe-Ser-Leu-Leu-Arg-Tyr-NH2 trifluoroacetate salt
應用
FSLLRY-NH2 三氟醋酸盐可作为蛋白酶激活受体 2（PAR2）抑制剂，在小鼠模型中测试其对尿路感染的影响。此外，它也用于研究特应性皮炎（AD）相关急性瘙痒骤然加重小鼠模型中中至重度 AD 3 期临床试验的临床瘙痒数据集。
生化／生理作用
FSLLRY-NH2 是蛋白酶激活受体 2（PAR2）的肽拮抗剂。在啮齿类动物模型中，肽阻断激动剂诱导瘙痒。在基于细胞的试验中，肽抑制激动剂诱导的心肌细胞重塑和内皮细胞产生细胞因子。
FSLLRY-NH2降低内脏超敏反应（VH）的能力表明 PAR2 参与了 VH 的维持。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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