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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 15 mg/mL, clear
儲存溫度
−20°C
InChI
1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1
InChI 密鑰
BURJAQFYNVMZDV-FIRIVFDPSA-N
生化／生理作用
Daurisoline alkaloid isolated from the rhizomes of Menispermum dauricum that exhibit varies pharmacological activities including antiplatelet aggregation, anti-inflammatory, neuron-protective properties, and antiarrhythmic effect. It appears that antiarrhythmic effect of daurisoline is maintained through blockade of hERG channels.
Daurisoline is antiarrythmic, anti-inflammatory, neuron-protective; and blocks hERG channels.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
T Wang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 33(4), 241-244 (2002-04-10)
O, O-acetyldaurisoline(Adau) is a derivative of daurisoline (Dau). In cultured PC12 cells, Adau was found to inhibit K+, Bay K8644 and norepinephrine induced intracellular free calcium concentration increase. Adau was also shown to protect PC12 cells from hypoxia-reoxygenation injury with
Z X Wang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 29(9), 647-651 (1994-01-01)
Standard microelectrode technique was used to study the effect of daurisoline (DS) on delayed afterdepolarization (DAD) and triggered activity (TA) in guinea pig ventricular trabeculae. DS (50 mumol.L-1) abolished TA induced by ouabain or caffeine, inhibited isoprenaline-induced TA, decreased incidence
J G Liu et al.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 20(1), 21-26 (1999-08-07)
To explore mechanisms of l-S.R-daurisoline (DS)-mediated protection of cultured hippocampal neurons from sodium glutamate (Glu) cytotoxicity. Cultured neurons obtained from rat hippocampus were used to examine the protective effect of DS against Glu neurotoxicity. Cell viability was estimated using trypan
Qiang-Ni Liu et al.
The American journal of Chinese medicine, 38(1), 37-49 (2010-02-04)
Our previous studies have shown that daurisoline (DS) exerted antiarrhythmic effects on various experimental arrhythmias. In this study, the effects of DS on early afterdepolarizations (EADs) and its possible mechanisms have been investigated. Cardiac hypertrophy was induced in rabbits by
J Liu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 33(3), 165-170 (2002-04-10)
In this study, the protective effects of (-)-R.R-daurisoline and its three optical isomers on ischemic injury in cultured PC12 cells induced by treating cells with NaCN in glucose-free medium were investigated. Cell viability was measured using MTT assay. The results
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