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化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
儲存溫度
2-8°C
SMILES 字串
Cc1onc(C(=O)N2CCN(CC2)C(c3ccc(Cl)cc3)c4ccc(Cl)cc4)c1[N+]([O-])=O
InChI
1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
InChI 密鑰
VIBHJPDPEVVDTB-UHFFFAOYSA-N
應用
ML 210 可用作含硒酶谷胱甘肽过氧化物酶 4（GPX4）的抑制剂，以诱导癌细胞的铁死亡。此外，还可作为 GPX4 抑制剂研究 GPX4 的药理性抑制功能是否改变了粘附 MCF10A 和 Hs578t 细胞中 prominin2 表达并影响铁死亡。
生化／生理作用
ML 210 可作为含硒酶谷胱甘肽过氧化物酶 4（GPX4）的抑制剂。它对少数卵巢癌细胞系表现出细胞毒性。
在表达 RAS 癌基因的肿瘤细胞中，ML 210 诱导非凋亡性细胞死亡。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Matthew J Hangauer et al.
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