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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
protect from light
顏色
white to beige
溶解度
H2O: ≥2 mg/mL
儲存溫度
2-8°C
SMILES 字串
O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
InChI
1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChI 密鑰
FUXFIVRTGHOMSO-UHFFFAOYSA-N
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應用
唑来膦酸一水合物用作：
- 作为抑制剂，抑制胶质母细胞瘤、乳腺癌肿瘤细胞 和前列腺癌细胞系LAPC4的增殖
- 与 D,L-丙交酯75：乙交酯25（PLGA）形成缀合物，分析其在股骨远端的骨形成功能
- 作为胶质母细胞瘤细胞中法尼基二磷酸合酶的抑制剂
生化／生理作用
唑来膦酸（唑来膦酸盐）是一种双膦酸盐骨吸收抑制剂，是基焦磷酸（FPP）合成酶的抑制剂，其会导致破骨细胞活性的下游抑制并减少骨吸收和转换。它已被用于治疗绝经后的骨质疏松症，佩吉特病、高钙血症，并结合癌症化疗以治疗已经扩散到骨骼的癌症引起的骨损伤。
準備報告
本品在溶液中极其不稳定，复溶后应尽快使用。如果一定要保存溶液，最多可在2-8ºC下存放24小时。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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