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![2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-8-ol AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/222/273/34d9c8c2-8285-4c85-84e2-ab2110133856/640/34d9c8c2-8285-4c85-84e2-ab2110133856.png)
品質等級
化驗
≥95% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
yellow
溶解度
DMSO: ≥15 mg/mL
儲存溫度
2-8°C
SMILES 字串
CCOc1cc(Br)c(Br)c(C=O)c1O
InChI
1S/C9H8Br2O3/c1-2-14-7-3-6(10)8(11)5(4-12)9(7)13/h3-4,13H,2H2,1H3
InChI 密鑰
MZAISYPWQNBWED-UHFFFAOYSA-N
應用
3-Ethoxy-5,6-dibromosalicylaldehyde was used to study modulation of autophagy, JNK activation and NF-κB-mediated inflammation.
生化／生理作用
3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1). It inhibits XBP-1 splicing induced pharmacologically in human cells. 3-Ethoxy-5,6-dibromosalicylaldehyde potently inhibits the endoribonuclease of IRE1 but does not inhibit RNases A, T1, or L.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Our previous study has shown that activation of JNK plays a critical role in Porcine reproductive and respiratory syndrome virus (PRRSV)-mediated apoptosis. In this follow-up study, we further investigated the mechanisms involved in modulation of PRRSV-mediated JNK activation and apoptosis.
Cristian González-Guerrero et al.
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Y Liu et al.
Apoptosis : an international journal on programmed cell death, 22(4), 544-557 (2017-02-12)
Quercetin (3,3',4',5,7-pentahydroxyflavone, Qu) is a promising cancer chemo-preventive agent for various cancers because it inhibits disease progression and promotes apoptotic cell death. In our previous study, we demonstrated that Qu could evoke ER stress to enhance drug cytotoxicity in ovarian
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