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Merck

SMB00436

Sigma-Aldrich

Pinoresinol diglucoside

≥98% (HPLC)

别名:

(+)-Pinoresinol 4,4′-O-bisglucopyranoside, Pinoresinol di-β-D-glucoside

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About This Item

经验公式(希尔记法):
C32H42O16
CAS号:
分子量:
682.67
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.25

品質等級

化驗

≥98% (HPLC)

形狀

powder

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

−20°C

SMILES 字串

O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC=C([C@H]3OC[C@@]4([H])[C@]3([H])CO[C@@H]4C5=CC=C(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(OC)=C5)C=C2OC)[C@@H]1O

InChI

1S/C32H42O16/c1-41-19-7-13(3-5-17(19)45-31-27(39)25(37)23(35)21(9-33)47-31)29-15-11-44-30(16(15)12-43-29)14-4-6-18(20(8-14)42-2)46-32-28(40)26(38)24(36)22(10-34)48-32/h3-8,15-16,21-40H,9-12H2,1-2H3/t15-,16-,21+,22+,23+,24+,25-,26-,27+,28+,29+,30+,31+,32+/m0/s1

InChI 密鑰

ZJSJQWDXAYNLNS-FUPWJLLWSA-N

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一般說明

Pinoresinol diglucoside (PDG) is an important lignan found in the bark of the traditional Chinese medicinal plant Eucommia ulmoides, also known as Tu-Chung. It is also associated with other plants such as Forsythia suspensa and Styrax spp. In plants, PDG is produced through the phenylpropanoid pathway.
Pinoresinol diglucoside is an important lignan found in the bark of the Eucommia ulmoides, which is known in traditional Chinese medicine as du zhong. In plants, pinoresinol diglucoside is produced through the phenylpropanoid pathway.

生化/生理作用

Pinoresinol diglucoside has antihypertensive properties. It serves as a α-glucosidase inhibitor. α-Glucosidase catalyzes the conversion of carbohydrates to glucose in the small intestine. Hence, pinoresinol diglucoside might be useful as an antidiabetic agent.
Pinoresinol diglucoside is a potent antihypertensive, anti-inflammatory and antioxidant agent. It also exerts tumor-suppressive and anti-osteoporotic properties. PDG serves as an α-glucosidase inhibitor that catalyzes the conversion of carbohydrates to glucose in the small intestine. Hence, it may serve as an antidiabetic agent in the management of diabetes. It displays neuroprotective properties by alleviating ischemic stroke-related brain injury in mice model.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Pinoresinol diglucoside is screened as a putative ?-glucosidase inhibiting compound in Actinidia arguta leaves
Kwon D, et al.
Journal of the Korean Society for Applied Biological Chemistry, 57(4) (2014)
Bioconversion of pinoresinol diglucoside and pinoresinol from substrates in the phenylpropanoid pathway by resting cells of Phomopsis sp. XP-8
Zhang Y, et al.
PLoS ONE, 10(9), e0137066-e0137066 (2015)
Structure identification and fermentation characteristics of pinoresinol diglucoside produced by Phomopsis sp. isolated from Eucommia ulmoides Oliv
Shi J , et al.
Applied Microbiology and Biotechnology, 93(4) (2012)
Zhenhong Gao et al.
Journal of microbiology and biotechnology, 27(8), 1428-1440 (2017-06-18)
Phomopsis sp. XP-8 (an endophytic fungus) was previously found to produce pinoresinol diglucoside (PDG), a major antihypertensive compound of Tu-Chung (the bark of Eucommia ulmoides Oliv.), which is widely used in Chinese traditional medicines. In the present study, two bioconversion
M Harada et al.
Hinyokika kiyo. Acta urologica Japonica, 38(2), 207-211 (1992-02-01)
A rare case of ureteral endometriosis is reported. A 46-year-old nulliparous woman was referred to our hospital because of right hydronephrosis which was detected by ultrasonography; Drip infusion pyelography showed right hydroureteronephrosis with the distal obstruction. MRI demonstrated right ovarian

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