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一般說明
我们全面的shRNA产品系列包括超过150,000个预克隆的shRNA构建体，靶向超过15,000个人类基因和15,000个小鼠基因。该文库可用于：基因家族集合：与特定功能类（如激酶和离子通道）相关的基因集合；基因靶标集合，针对靶标基因的shRNA克隆集合；以及单个shRNA克隆。我们的shRNA和慢病毒制造平台利用专门实验室，配备最先进的机器人技术、液体处理和实验室信息管理系统（LIMS），为您的RNAi研究需求提供卓越的质量和服务。
MISSION® TRC shRNA bacterial glycerol stocks offer a renewable resource for shRNA plasmids. These plasmids can then be transfected directly, or packaged into lentiviral particles.
應用
MISSION® shRNA has been used in the generation of damage-regulated autophagy modulator (DRAM) and p73 knockdown cell lines. It has also been used in lentivirus generation and gene knockdown and to investigate the contribution of PAX8 (paired box 8) in ovarian cancer progression.
其他說明
想要查看实验方案和应用数据，请访问 sigma.com/shrna。
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells
Di P, et al.
BMC Cancer, 14(1), 292-292 (2014)
Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells
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Cellular and molecular gastroenterology and hepatology, 7(4), 819-839 (2019-03-05)
The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous lesions or polyps is not known. Here
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Expression of the voltage gated proton channel (Hv1) as identified by immunocytochemistry has been reported previously in breast cancer tissue. Increased expression of HV1 was correlated with poor prognosis and decreased overall and disease-free survival but the mechanism of its
Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma
Huang Y, et al.
Blood, 125(9), 1435-1443 (2015)
商品
MISSION shRNA reduce the expression of specific target genes by targeting the specific mRNA therefore reducing the corresponding protein expression.
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