SBR00065

Rifampicin Ready Made Solution

50 mg/mL in DMSO

• 经验公式（希尔记法）: C₄₃H₅₈N₄O₁₂
• CAS号: 13292-46-1
• 分子量: 822.94
• 分類程式碼代碼: 41116107
• NACRES: NA.76

属性

• 形狀: liquid
• 品質等級: 200
• 比活性: Antibacterial
• 濃度: 50 mg/mL in DMSO
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; viruses
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C
• SMILES 字串: N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O
• InChI: 1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
• InChI 密鑰: JQXXHWHPUNPDRT-WLSIYKJHSA-N

说明

一般說明

Rifampicin is a microlide antibiotic effective against gram-positive and gram-negative bacteria, mycobacteria and viruses.

應用

• Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.
• Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).
• Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.
• Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.

生化／生理作用

Inhibits the assembly of DNA and protein into mature virus particles.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

其他說明

The product is supplied in DMSO at a concentration of 50 mg/mL. Working concentrations for agrobacterium selection are typically 10-50 mg/L.

安全信息

• 危險聲明: H362
• 防範說明: P201 - P202 - P263 - P264 - P270 - P308 + P313
• 危險分類: Lact.
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 188.6 °F - closed cup
• 閃點（°C）: 87 °C - closed cup