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Merck
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主要文件

SAB5500134

Sigma-Aldrich

Anti-KI-67 antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP6, tissue culture supernatant

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

重組細胞

expressed in proprietary host

共軛

unconjugated

抗體表格

tissue culture supernatant

抗體產品種類

primary antibodies

無性繁殖

SP6, monoclonal

物種活性

human (tested)

物種活性(以同源性預測)

bovine

技術

immunohistochemistry: 1:200

同型

IgG

UniProt登錄號

運輸包裝

wet ice

儲存溫度

2-8°C

目標翻譯後修改

unmodified

基因資訊

human ... MKI67(4288)

一般說明

Ki-67 is a nuclear protein, which is expressed in the proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
The gene marker of proliferation Ki-67 (MKI67), spanning 15 exons, is mapped to human chromosome 10q26.2. The encoded protein contains phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal. It possesses 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.

免疫原

Synthetic peptide from C-terminus of human Ki-67 protein.

應用

Anti-KI-67 antibody, Rabbit monoclonal has been used in immunohistochemistry.

生化/生理作用

Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, functions as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered to be a potent cell proliferation marker.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

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