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一般說明
B-cell lymphoma 2 (BCL-2) is an anti-apoptotic and target gene of nuclear factor-κB (NF-κB). The protein is expressed in the nuclear envelope, mitochondria and endoplasmic reticulum. The gene encoding BCL-2 is localized on human chromosome 18q21.
免疫原
Synthetic peptide corresponding to N-terminus of human BCL-2 alpha protein.
生化／生理作用
B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas. Expression of BCL-2α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2α protein, whereas the normal or hyperplastic germinal centers are negative.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
P. Riederer
Advances in Research on Neurodegeneration null
Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP and Taglialatela G
The Journal of Biological Chemistry, 281(52), 40493-40502 (2006)
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.
Stornaiuolo M
Journal of Medicinal Chemistry, 58(5), 2135-2148 (2015)
Maartje van der Heijden et al.
Nature communications, 7, 10916-10916 (2016-03-10)
Intestinal tumour formation is generally thought to occur following mutational events in the stem cell pool. However, active NF-κB signalling additionally facilitates malignant transformation of differentiated cells. We hypothesized that genes shared between NF-κB and intestinal stem cell (ISCs) signatures
Xiaopeng Wang et al.
Molecular medicine reports, 23(2) (2020-12-11)
Acute progressive hypoxic respiratory failure caused by various predisposing factors is known as acute respiratory distress syndrome (ARDS). Although penehyclidine hydrochloride (PHC), an anticholinergic drug, is widely applied in clinical practice, the specific mechanisms underlying PHC in the treatment of
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