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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 76 kDa
物種活性
human
濃度
~1 mg/mL
技術
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... C1S(716)
一般說明
Anti-C1S Antibody detects endogenous levels of total C1S protein.
The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.
免疫原
The antiserum was produced against synthesized peptide derived from human C1S.
Immunogen Range: 541-590
Immunogen Range: 541-590
生化／生理作用
Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated with lupus nephritis, with low gene expression observed in mice.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Elucidation of the substrate specificity of the C1s protease of the classical complement pathway.
Kerr FK
The Journal of Biological Chemistry, 280(47), 39510-39514 (2005)
Gene expression analysis detected a low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice
Tamura K
Nephron: Experimental Nephrology, 123(3-4), 34-45 (2013)
Complement genetics, deficiencies, and disease associations
Mayilyan KR
Protein & cell, 3(7), 487?496-487?496 (2012)
Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.
Duncan RC
Journal of Immunology, 189(5), 2365-2373 (2012)
Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites
Isabelle Bally
Proceedings of the National Academy of Sciences of the USA, 110(21), 8650?8655-8650?8655 (2013)
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