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Merck

SAB4200462

Sigma-Aldrich

Anti-Claudin-1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

别名:

Anti-CLD1, Anti-CLDN1, Anti-ILVASC, Anti-SEMP1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen ~23 kDa

物種活性

human, rat

濃度

~1.0 mg/mL

技術

immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat kidney.
western blot: 1.5-3.0 μg/mL using extracts of rat kidney (S1 fraction).

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CLDN1(9076)
rat ... Cldn1(65129)

一般說明

Anti-Claudin-1 is produced in rabbit using as immunogen a synthetic peptide corresponding to a sequence located at the C-terminal region of human claudin-1, conjugated to KLH. Claudin-1 (also known as CLDN1, senescence-associated epithelial membrane protein (SEMP1) and ILVASC) is a 22 kDa protein. It is expressed at high levels in kidney and liver and at lower levels in spleen, heart, brain, lung and testis. Claudins are located in both epithelial and endothelial cells in tissues. Claudins consist of four transmembrane domains and two extracellular loops, required to form tight junction strands. CLDN1 gene is located on human chromosome 3q28.

免疫原

synthetic peptide corresponding to a sequence located at the C-terminal region of human claudin-1, conjugated to KLH. The corresponding sequence is identical in rat claudin-1 and highly conserved (single amino acid substitution) in mouse claudin-1.

應用

Anti-Claudin-1 antibody produced in rabbit has been used in immunohistochemistry and immunoblotting,

生化/生理作用

Claudin-1 is frequently up-regulated in colorectal carcinomas (CRCs), resulting in tumor differentiation and progression. Defects in the gene encoding claudin-1 are the cause of an autosomal recessive syndrome named ichthyosis-sclerosing cholangitis neonatal (NISCH). It participates in the barrier formation of tight junction. It modulates the tight junctions in human airway epithelium. CLDN1 acts as a receptor for the hepatitis C virus entry.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

Taurine supplementation alleviates puromycin aminonucleoside damage by modulating endoplasmic reticulum stress and mitochondrial-related apoptosis in rat kidney
Stacchiotti A, et al.
Nutrients, 10(6), 689-689 (2018)
Claudin association with CD81 defines hepatitis C virus entry
Harris HJ, et al.
Test, jbc-M110 (2010)
Claudin association with CD81 defines hepatitis C virus entry
Harris HJ, et al.
The Journal of biological chemistry, jbc-M110 (2010)
Claudin association with CD81 defines hepatitis C virus entry
Harris HJ, et al.
The Journal of Biological Chemistry, jbc-M110 (2010)
Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags
Hackl MJ, et al.
Nature Medicine, 19(12), 1661-1661 (2013)

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