推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~125 kDa
物種活性
rat, human
濃度
1 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
同型
IgG
免疫原序列
(G-D-Y-G-Q)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... JAK2(3717)
一般說明
JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of protein. It is located on chromosome 9p24.
免疫原
Peptide sequence around aa. 568-572 (G-D-Y-G-Q), according to the protein JAK2.
生化／生理作用
JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
Plays a role in leptin signaling and control of body weight.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2
Joos S, et al.
International Journal of Cancer. Journal International Du Cancer, 103(4), 489-495 (2003)
Jak2 is essential for signaling through a variety of cytokine receptors
Parganas E, et al.
Cell, 93(3), 385-395 (1998)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Borriello L
Cancer Research, 77(18), 5142-5157 (2017)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)
Lin Miao et al.
Cancer immunology, immunotherapy : CII, 63(7), 699-711 (2014-04-11)
Gastric cancer remains the second leading cause of cancer-related deaths worldwide. Although Helicobacter pylori (H. pylori) is considered to be a critical risk factor, the molecular mechanisms underlying H. pylori-induced gastric carcinogenesis are still poorly defined. Recently, accumulating studies have
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