生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~125 kDa
物種活性
mouse, rat, human
濃度
1 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(K-E-YP-Y-K)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr1007)
基因資訊
human ... JAK2(3717)
一般說明
Janus kinase 2(JAK2) mapped on human chromosome 9p24, encodes a tyrosine kinase. The encoded protein is a member of the Jak family of protein. JAK2 is ubiquitously expressed. This protein contains a catalytic domain and protein–protein interaction domain.
免疫原
Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K), according to the protein JAK2.
生化／生理作用
Janus kinase 2(JAK2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy. In addition, mutations in the gene has also been observed in polycythaemia vera patients.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
Plays a role in leptin signaling and control of body weight.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our 产品选型工具.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Parganas E
Cell, 93, 385-395 (1998)
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.
Joos S
International Journal of Cancer. Journal International Du Cancer, 103, 489-495 (2003)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7, 188-201 (2017)
A TEL-JAK2 Fusion Protein with Constitutive
Kinase Activity in Human Leukemia
Lacronique V
Science, 278, 1309-1312 (1997)
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
James C
Nature, 434, 1144-1148 (2005)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门