生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~88 kDa
物種活性
mouse, human, rat
濃度
1 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(P-M-SP-P-R)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer727)
基因資訊
human ... STAT3(6774)
一般說明
信号传感器和转录激活因子3 (STAT3)是白介素-6- (IL-6)激活的急性期反应因子(APRF)复合物的组成部分，属于信号传感器和转录激活因子(STAT)家族。在所有类型的组织中都有表达。STAT3基因有24个外显子，定位于人类染色体17q21.2。
免疫原
基于蛋白质STAT3的丝氨酸727（PMS（p）-PR）磷酸化位点周围的肽序列。
應用
兔产生的抗磷酸化stat3 (pSer727)抗体已被用于免疫印迹(1:1000)和免疫荧光染色(1:20 00)。
生化／生理作用
信号传感器和转录激活因子3 (STAT3)蛋白在细胞生长、凋亡、代谢、细胞呼吸和自噬中起关键作用。它可能是糖皮质激素受体信号转导的共激活物。STAT3可调节转录。它参与脊椎动物的发育以及炎症和免疫的调节。可能参与气道炎症、过敏和哮喘。STAT3基因突变与免疫缺陷、自身免疫和癌症相关。
特點和優勢
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
標靶描述
能与多种急性期蛋白基因启动子中所鉴定的白介素6（IL-6）反应元件结合的转录因子。其可由IL31通过IL31RA进行激活。
外觀
溶于含有0.02％叠氮化钠和50%甘油的磷酸盐缓冲盐水
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Emily J Hillmer et al.
Cytokine & growth factor reviews, 31, 1-15 (2016-05-18)
The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer. Strikingly, however, either hyperactivation or inactivation of
Fabian Gärtner et al.
Frontiers in immunology, 12, 745132-745132 (2021-12-07)
Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The immune response requires tight regulation and can be influenced by additional risk factors such as obesity, which is considered a state of chronic inflammation. Utilizing high-dimensional mass
Aihong Wang et al.
Biology open, 8(9) (2019-09-04)
Human epididymis protein 4 (HE4) is well known to be a predictor of ovarian cancer clinically. HE4 is reported to play crucial roles in ovarian cancer progression and metastasis. The purpose of the present study was to explore its biological
Xiaoping Pan et al.
Life sciences, 214, 124-135 (2018-11-06)
Although the anti-neoplastic effects of physcion are well documented, its specific action in hepatocellular carcinoma (HCC) is not understood. Taken together, physcion is a promising drug candidate for the treatment and prevention of HCC. Cell Counting Kit-8 (CCK-8) assay utilized
Ilaria Marrocco et al.
Cells, 8(9) (2019-09-11)
Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes. A bioinformatic analysis indicated a
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