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一般說明
Fetuin A, also known as Alpha-2-HS-glycoprotein (AHSG), Alpha-2-Z-globulin or Ba-alpha-2-glycoprotein, is a member of the cystatin superfamily of cysteine protease inhibitors. Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver Hepatocytes. It is cleaved into two chains bound by disulfide bonds and inhibits ectopic Ca×PO4 ion precipitation and vascular calcification.
Monoclonal Anti-Fetuin A (mouse IgM isotype) is derived from the Fet A-M hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a BALB/C mouse immunized with a synthetic peptide corresponding to the internal region of human AHSG (Fetuin A), conjugated to KLH as immunogen. Fetuin A is a 64 kDa protein, predominantly localized to the blood.
特異性
Monoclonal Anti-Fetuin A specifically recognizes Fetuin A from human plasma.
免疫原
Synthetic peptide corresponding to human Fution A internal region, conjugated to KLH
應用
The antibody is recommended for use in various immunological techniques including Immunoblotting, Immunohistochemistry and ELISA.
生化／生理作用
Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver hepatocytes. It is cleaved into two chains bound by disulphide bonds and inhibits ectopic Ca×PO4 ion precipitation and vascular calcification.
Reduction in the serum fetuin might indicate coronary artery disease. Fetuin is also implicated in insulin resistance and metabolic syndrome. Increased levels of fetuin A is observed in non-alcoholic fatty liver disease.
Reduction in the serum fetuin might indicate coronary artery disease. Fetuin is also implicated in insulin resistance and metabolic syndrome. Increased levels of fetuin A is observed in non-alcoholic fatty liver disease.
Fetuin A is consider to be a negative acute-phase reactant and its serum concentration decreases in response to inflammation, compared with normal levels. In addition, it acts as a mineral chaperone to facilitate the transport and removal of potentially proinflammatory and procalcific cargo (waste).Fetuin A plays a major role in numerous diseases and pathophysiological conditions involved with calcium metabolisms.
外觀
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
儲存和穩定性
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Peter Stenvinkel et al.
Kidney international, 67(6), 2383-2392 (2005-05-11)
Vascular calcification is common among end-stage renal disease (ESRD) patients and a central characteristic of the atherosclerotic cardiovascular disease observed in dialysis patients. Fetuin-A, a circulating calcium-regulatory glycoprotein that inhibits vascular calcification, is associated with inflammation and outcome in dialysis
Emerging human Fetuin A assays for biomedical diagnostics
Vashist SK, et al.
Trends in biotechnology, 35(5), 407-421 (2017)
The relationship of circulating fetuin-a with liver histology and biomarkers of systemic inflammation in nondiabetic subjects with nonalcoholic fatty liver disease
Celebi G, et al.
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 21(3), 139-139 (2015)
Vladimír Bláha et al.
Clinical biochemistry, 42(10-11), 996-1000 (2009-04-04)
The purpose of this study was to assess whether low serum levels of fetuin-A are potential biochemical predictor of early and/or late survival in chronic hemodialysis (HD) patients. We measured serum levels of fetuin-A in 67 patients on chronic HD
Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions
Kutikhin AG, et al.
Scientific Reports, 6, 27255-27255 (2016)
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