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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 225 kDa (rat)
antigen ~150 kDa (Human)
物種活性
rat, chicken, human
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1.5 mg/mL
技術
indirect immunofluorescence: 2-4 μg/mL using chicken embryo fibroblast cells
western blot: 1-2 μg/mL using HEK-293T cell lysates overexpressing human tensin1
western blot: 1.5-3.0 μg/mL using lysates of A10 cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TNS1(7145)
rat ... Tns1(301509)
相关类别
一般說明
Tensins are a new family of focal adhesion proteins that link between the extracellular matrix (ECM) and the cytoskeleton via integrins. The tensin family includes four members: tensin1-4, encoded by different genes. Tensins are multidomain proteins consisting of homologous C1, protein tyrosine phosphatase (PTPase), C2, SH2 and PTB domains. Tensin 1 (also known as TNS1), shares extensive homology with tensin 2 and tensin 3 at its N- and C-terminal regions. Tensin 1 mRNA is broadly expressed in mouse embryo and various human tissues and is localized to focal adhesions.
免疫原
synthetic peptide corresponding to a sequence located near the C-terminus of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.
應用
Anti-Tensin 1 (C-terminal region) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化／生理作用
Tensin 1 plays an important role in regulating cell polarization, shape, motility and invasion. Tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Regulation of tensin-promoted cell migration by its focal adhesion localization and the SH2 domain
Chen H and Lo SH
The Biochemical Journal, 370, 1039-1045 (2003)
Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin
Hafizi S, et al.
Biochemical and biophysical research communications, 299(5), 793-800 (2002)
Alexandra Woychek et al.
Cytoskeleton (Hoboken, N.J.), 76(2), 200-208 (2019-01-23)
The nuclear envelope protein nesprin-2G is a component of the linker of nucleoskeleton and cytoskeleton (LINC) complex and is responsible for mechanical and signaling crosstalk between the nucleus and cytoskeleton. A prior study has demonstrated that nesprin-2G knockout mice show
Alexandra Woychek et al.
Cytoskeleton (Hoboken, N.J.), 76(2), 200-208 (2019-01-23)
The nuclear envelope protein nesprin-2G is a component of the linker of nucleoskeleton and cytoskeleton (LINC) complex and is responsible for mechanical and signaling crosstalk between the nucleus and cytoskeleton. A prior study has demonstrated that nesprin-2G knockout mice show
Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration
Chen H, et al.
Proceedings of the National Academy of Sciences of the USA, 99(2), 733-738 (2002)
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