跳转至内容
Merck
所有图片(1)

Key Documents

SAB2501252

Sigma-Aldrich

Anti-CLEC4C antibody produced in goat

affinity isolated antibody, buffered aqueous solution

别名:

Anti-BDCA2, Anti-CD303, Anti-CLECSF11, Anti-CLECSF7, C-type lectin domain family 4, member C

登录查看公司和协议定价


About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

goat

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human

技術

indirect ELISA: suitable
western blot: suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CLEC4C(170482)

一般說明

C-type lectin domain family 4 member C (CLEC4C) is also known as blood dendritic cell antigen 2. It is expressed on plasmacytoid dendritic cells. CLEC4C is a type II transmembrane protein belonging to the C-type lectin (CTLs) superfamily. The protein consists of an extracellular carbohydrate recognition domain (CRD), a transmembrane region and a short cytoplasmic domain. The gene encoding CLEC4C is localized on human chromosome 12.

免疫原

Peptide with sequence QSWTKSQKNCSV, from the Internal region of the protein sequence according to NP_569708.1; NP_987099.1.

生化/生理作用

C-type lectin domain family 4 member C (CLEC4C) is involved in intracellular signal transduction through the transmembrane adaptor, FcεRγ. It inhibits the secretion of soluble TNF-related apoptosis-inducing ligand (TRAIL). CLEC4C may have a role in ligand internalization.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品?  

试试我们的产品选型工具.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.
Jegouzo SA
The Journal of Biological Chemistry, 290(27), 16759-16771 (2015)
Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides.
Riboldi E
The Journal of Biological Chemistry, 35329-35333 (2011)
BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.
Dzionek A
The Journal of Experimental Medicine, 194(12), 1823-1834 (2001)
Amy H Lin et al.
Journal of virology, 88(17), 10066-10077 (2014-06-27)
We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门