推荐产品
生物源
goat
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
技術
ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TACSTD2(4070)
一般說明
Tumor associated calcium signal transducer 2 (TACSTD2), also known as trophoblast cell surface antigen 2 (TROP2), is a 36 kDa protein and part of the TACSTD family. The gene encoding this cell surface glycoprotein is localized on human chromosome 1p32.1.
免疫原
Peptide with sequence C-HYEQPTIQIELRQN from the internal region of the protein sequence according to NP_002344.2.
生化／生理作用
Trophoblast cell surface antigen 2 (TROP2) has a role in epithelial-mesenchymal transition. It modulates stem cell activity and is crucial in promoting cell self-renewal and survival. TROP2 increases intracellular calcium levels. The protein is overexpressed in many cancers. It has been shown to influence the proliferation and migration of gallbladder cancer cells.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Overexpression of trophoblast cell surface antigen 2 as an independent marker for a poor prognosis and as a potential therapeutic target in epithelial ovarian carcinoma.
Xu N,et al.
International Journal of Experimental Pathology, 97(2), 150-158 (2016)
TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT.
Li X, et al.
Oncotarget, 8(29), 47052-47052 (2017)
TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity.
Fong D, et al.
Modern Pathology, 21(2), 186-186 (2008)
Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease.
Liu Q, et al.
Respiratory Research, 17(1), 159-159 (2016)
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