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應用
金黄色葡萄球菌鞘氨醇酶已用于：
- 二甲胺四环素诱导大鼠皮层神经毒性的研究
- 血清样品中的鞘磷脂浓度测定
- 增强鞘磷脂酶活性，研究 PARK9 介导的外泌体生物发生
生化／生理作用
启动形成基于鞘磷脂的第二信使。激活MAPK（丝裂原活化蛋白激酶）和SAPKs（应激活化蛋白激酶）；由鞘磷脂生成神经酰胺。
细菌鞘磷脂酶在中性 pH 下具有活性。用于体外细胞培养时，它会水解质膜外叶上的鞘磷脂，并产生脂溶性神经酰胺。鞘磷脂酶是鞘磷脂酶/神经酰胺途径中的关键酶，与几种神经退行性疾病的发病机制有关。
單位定義
在pH 7.4和37℃条件下，1个单位将每分钟水解1.0 μmol TNPAL-鞘磷脂。
外觀
溶于含0.25 M磷酸盐缓冲液的50%甘油，pH 7.5
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Elin Rebecka Carlsson et al.
Frontiers in endocrinology, 9, 172-172 (2018-06-21)
Metabolic surgery is superior to lifestyle intervention in reducing weight and lowering glycemia and recently suggested as treatment for type 2 diabetes mellitus. Especially Roux-en-Y gastric bypass (RYGB) has been focus for much research, but still the mechanisms of action
Measurement of sphingomyelin and ceramide cellular levels after sphingomyelinase-mediated sphingomyelin hydrolysis.
P Santana et al.
Methods in molecular biology (Clifton, N.J.), 105, 217-221 (1999-07-31)
Anne M Brauweiler et al.
The Journal of allergy and clinical immunology, 131(2), 421-427 (2012-12-19)
The skin of patients with atopic dermatitis (AD) has defects in keratinocyte differentiation, particularly in expression of the epidermal barrier protein filaggrin. AD skin lesions are often exacerbated by Staphylococcus aureus-mediated secretion of the virulence factor α-toxin. It is unknown
Lysosomal enzyme defects and Parkinson disease.
Nutan Sharma
Neurology, 80(17), 1544-1545 (2013-03-29)
Benoît-Joseph Laventie et al.
The Biochemical journal, 450(3), 559-571 (2013-01-04)
PVL (Panton-Valentine leukocidin) and other Staphylococcus aureus β-stranded pore-forming toxins are important virulence factors involved in various pathologies that are often necrotizing. The present study characterized leukotoxin inhibition by selected SCns (p-sulfonato-calix[n]arenes): SC4, SC6 and SC8. These chemicals have no
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