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Merck

S6701

Sigma-Aldrich

SF-11

≥98% (HPLC)

别名:

N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide, SID 17507305

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About This Item

经验公式(希尔记法):
C27H30N2O2S
分子量:
446.60
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

DMSO: ≥20 mg/mL

儲存溫度

2-8°C

SMILES 字串

CCOc1ccc(NC(=S)N2CCC(CC2)C(O)(c3ccccc3)c4ccccc4)cc1

InChI

1S/C27H30N2O2S/c1-2-31-25-15-13-24(14-16-25)28-26(32)29-19-17-23(18-20-29)27(30,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-16,23,30H,2,17-20H2,1H3,(H,28,32)

InChI 密鑰

PMEQBGAGFZDWQX-UHFFFAOYSA-N

應用

SF-11 may be used in NPY Y2 receptor-mediated studies.

生化/生理作用

Radioligand studies reveal that SF-11 also targets 5-HT2B and dopamine transporter.1
SF-11 is a potent, selective NPY Y2 receptor antagonist; brain-penetrant.

特點和優勢

This compound is featured on the Neuropeptide Y Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Shaun P Brothers et al.
Molecular pharmacology, 77(1), 46-57 (2009-10-20)
The role of neuropeptide Y Y2 receptor (Y2R) in human diseases such as obesity, mood disorders, and alcoholism could be better resolved by the use of small-molecule chemical probes that are substantially different from the currently available Y2R antagonist, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide)

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