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Merck

S6508

Sigma-Aldrich

正钒酸钠

≥90% (titration)

别名:

Trisodium vanadate

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About This Item

线性分子式:
Na3VO4
CAS号:
分子量:
183.91
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

化驗

≥90% (titration)

形狀

crystalline powder

反應適用性

reagent type: catalyst
core: vanadium

顏色

white to off-white

mp

850-866 °C (lit.)

溶解度

H2O: soluble

SMILES 字串

[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

InChI 密鑰

IHIXIJGXTJIKRB-UHFFFAOYSA-N

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應用

正钒酸钠被用于制备胰岛素受体激酶脱磷酸化检测的终止液。26 它是用于开发利用表面固定抗体的Matrix ChIP的试剂之一。27

生化/生理作用

正钒酸钠可抑制辐射触发的p53介导的细胞凋亡激活。它减少了小鼠全身辐照引起的造血综合征、造血功能和延迟遗传毒性效应的不利影响。24 正钒酸盐与甲萘醌联合使用,可以防止脱落人胶质瘤细胞在抗癌药作用下发生迁移。25
抑制 ATP 酶、碱性磷酸酶和酪氨酸磷酸酶。在酸性 PH 值下形成的十钒酸盐可抑制肌醇基 1,4,5-三磷酸 (IP3)-诱导 Ca2+ 从内分泌细胞中的释放以及阻止 IP3 与其受体在脑组织中的结合。

特點和優勢

《受体分类和信号转导》手册的 磷蛋白磷酸酶(酪氨酸) 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
该化合物是激酶磷酸酶生物学研究的特色产品。点击此处 ,查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due
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Development (Cambridge, England), 142(1), 41-50 (2014-12-07)
Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic

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