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Key Documents

567540

Sigma-Aldrich

原钒酸钠

A broad spectrum potent inhibitor of protein tyrosine phosphatases.

别名:

原钒酸钠, PTP抑制剂X

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About This Item

经验公式(希尔记法):
Na3O4V
CAS号:
分子量:
183.91
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.77

品質等級

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze

顏色

white to off-white

溶解度

water: 10 mg/mL

運輸包裝

ambient

儲存溫度

10-30°C

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

InChI 密鑰

IHIXIJGXTJIKRB-UHFFFAOYSA-N

一般說明

一种广谱有效的蛋白质酪氨酸磷酸酶抑制剂。也可抑制Na+、K+-ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶。在微摩尔范围内,还抑制鼠伤寒沙门氏菌麦芽糖(MalFGK2)重组结合蛋白依赖性ATP结合盒(ABC)转运体的ATP酶活性。可通过过氧化氢转化为过钒酸盐。
一种广谱有效的蛋白质酪氨酸磷酸酶抑制剂。也可抑制Na+、K+ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶。最近研究表明,在微摩尔范围内,可抑制鼠伤寒沙门氏菌麦芽糖(MalFGK2)重组结合蛋白依赖性ATP结合盒(ABC)转运体的ATP酶活性。可通过过氧化氢转化为过钒酸盐。

生化/生理作用

主要靶标
Na+、K+-ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶
产物不与ATP竞争。
可逆:否
细胞可渗透性:否

警告

毒性:有害(C)

重構

复溶后,等分并冷冻保存(-20°C)。贮备溶液在-20°C下可稳定保存至多3个月。

其他說明

Huyer, G., et al. 1997.J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995.Biochem.Biophys.Res. Commun.216, 589.
Levchuck, S.G., et al. 1994.Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989.Biochem.J.262, 83.
Swarup, G., et al. 1982.Biochem.Biophys.Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A.1979.Biochem.J.181, 247.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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