S6201

Salinomycin, Ready Made Solution

from Streptomyces albus, ≥98% (HPLC)

• 别名: Antibiotic 61477, Coxxistac
• 经验公式（希尔记法）: C₄₂H₇₀O₁₁
• 分子量: 751.00
• MDL號碼: MFCD25541652
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329824560
• NACRES: NA.77

属性

• 生物源: Streptomyces albus
• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 濃度: 2 mg/ml
• 溶解度: DMSO: soluble; H₂O: insoluble; alcohols: soluble; carbon tetrachloride: soluble; chloroform: soluble; ethers and esters: soluble; hexane: soluble
• 抗生素活性譜: neoplastics
• 作用方式: cell membrane | interferes
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: C[C@@H]1O[C@]([C@]2(C)CC[C@]3([C@H](O)C=C[C@]4(O[C@@]([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@@]5([H])[C@@H](C)CC[C@@]([C@H](C(O)=O)CC)([H])O5)=O)([H])[C@@H](C)C[C@H]4C)O3)O2)([H])CC[C@]1(O)CC
• InChI: 1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1
• InChI 密鑰: KQXDHUJYNAXLNZ-XQSDOZFQSA-N

说明

一般說明

Chemical structure: polyether

應用

Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells. It has also been used in sequential treatment of cancer cells to study resistance.

生化／生理作用

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K⁺ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K⁺ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.

外觀

The product is supplied as a 2 mg/mL (2.66 mM) solution in DMSO, 0.2 μm-filtered.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 188.6 °F - closed cup
• 閃點（°C）: 87 °C - closed cup