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Merck

S4572

Sigma-Aldrich

SANT-1 型

≥98% (HPLC), powder, SHH antagonist

别名:

(4-苄基-哌嗪-1-基)-(3,5-二甲基-1-苯基-1H-吡唑-4-基亚甲基)-胺

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About This Item

经验公式(希尔记法):
C23H27N5
分子量:
373.49
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

产品名称

SANT-1 型, ≥98% (HPLC), powder

品質等級

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMSO: 5 mg/mL, clear (warmed)

儲存溫度

−20°C

SMILES 字串

Cc1nn(-c2ccccc2)c(C)c1\C=N\N3CCN(CC3)Cc4ccccc4

InChI

1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+

InChI 密鑰

FOORCIAZMIWALX-JJIBRWJFSA-N

應用

  • SANT-1已被用于:治疗细胞并研究并研究SANT1介导的抑制对刺猬信号传导的影响
  • 功能性人胰腺细胞的体外生成
  • 处理间变性淋巴瘤激酶(ALK)阳性间变性大细胞淋巴瘤细胞2和慢性淋巴细胞白血病细胞3引起SANT-1诱导的细胞死亡

生化/生理作用

SANT-1 是一种有效的 sonic hedgehog 信号途径(Shh)拮抗剂。
SANT-1 是一种有效的 sonic hedgehog 信号途径(Shh)拮抗剂,通过与平滑(Smo)受体结合直接抑制。SANT-1 抑制野生型和致癌 Smo 的效率相同。
众所周知SANT-1通过Ras/NF-κB途径诱导胶质母细胞瘤细胞凋亡。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Deobrat Dixit et al.
Cancer letters, 336(2), 347-358 (2013-04-04)
Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade
P Desch et al.
Oncogene, 29(35), 4885-4895 (2010-07-07)
The Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in healthy B lymphocytes. Profiling of cognate Hh pathway members
Rajesh R Singh et al.
Cancer research, 69(6), 2550-2558 (2009-02-27)
Deregulation of the sonic hedgehog (SHH) signaling pathway has been implicated in several cancers but has not been explored in T-cell lymphomas. Here, we report that the SHH/GLI1 signaling pathway is activated in anaplastic lymphoma kinase (ALK)-positive anaplastic large cell
Sigrid Nachtergaele et al.
eLife, 2, e01340-e01340 (2013-10-31)
The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate
Feorillo Galivo et al.
PloS one, 12(8), e0181812-e0181812 (2017-08-17)
The gallbladder and cystic duct (GBCs) are parts of the extrahepatic biliary tree and share a common developmental origin with the ventral pancreas. Here, we report on the very first genetic reprogramming of patient-derived human GBCs to β-like cells for

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