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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~40 kDa
物種活性
human
濃度
~1 mg/mL
技術
indirect immunofluorescence: suitable
western blot: 0.5-1 μg/mL using whole extracts of human U87 cells
western blot: 2.5-5 μg/mL using human HeLa cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SIRT6(51548)
一般說明
Sirtuin 6 (Sirt6) is a nuclear, chromatin-associated protein. Sirt6 is a member of Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.
免疫原
synthetic peptide corresponding to amino acids 330-348 of human Sirt6.
應用
Anti-Sirt6 (C-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
- immunohistochemistry
生化／生理作用
Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD+ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of incretin treatment
Balestrieri M L, et al.
Diabetes, 64(4), 1395-1406 (2015)
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
Mao Z, et al.
Proceedings of the National Academy of Sciences of the USA, 109(29), 11800-11805 (2012)
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells
Lappas, Martha
Mediators of Inflammation, 2012 (2012)
Longsen Han et al.
Scientific reports, 5, 15366-15366 (2015-10-21)
Sirt6, a member of the sirtuin family of NAD-dependent protein deacetylases, has been implicated in multiple biological processes. However, the roles of Sirt6 in meiosis have not been addressed. In the present study, by employing knockdown analysis in mouse oocytes
Juan Ge et al.
Aging, 11(7), 1965-1976 (2019-03-31)
It has been well recognized that oocyte quality declines in aging animals. However, to date, the underlying mechanism remains to be explored. In the present study, we report that oocytes and embryos from aged mice (42-45 weeks old) display the
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