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About This Item
经验公式（希尔记法）:
C20H10F6N2OS
CAS号:
分子量:
440.36
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥98% (HPLC)
形狀
solid
儲存條件
protect from light
顏色
white
mp
94.5-95.3 °C
溶解度
DMSO: ≥10 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F
InChI
1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
InChI 密鑰
OYMNPJXKQVTQTR-UHFFFAOYSA-N
基因資訊
human ... S1PR1(1901) , S1PR2(9294) , S1PR3(1903) , S1PR4(8698) , S1PR5(53637)
應用
SEW2871可用于模拟HUVEC中的1-磷酸鞘氨醇的作用，以研究长穿透素3所产生的先天免疫力。
SEW2871已被用作鞘氨醇-1磷酸酯（S1P）受体激动剂，用于测定重构血浆载脂蛋白（ApoM) /S1P对小鼠血管通透性的作用。
生化／生理作用
SEW2871是1-磷酸鞘氨醇受体的选择性激动剂。其会通过显著延长室性心动过速和室颤的持续时间，加剧再灌注性心律失常。 SEW2871可通过影响淋巴细胞归巢和细胞迁移来调节炎症反应。 通过抑制促炎分子，SEW2871可减少因缺血引起的急性肾衰竭。
新型选择性人鞘氨醇-1-磷酸亚型1（S1P1）受体激动剂。
包裝
光敏。
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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