推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white
溶解度
DMSO: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
InChI
1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
InChI 密鑰
DMWVGXGXHPOEPT-UHFFFAOYSA-N
應用
Src抑制剂-1可用于Src激酶介导的细胞信号转导研究。
生化／生理作用
Src抑制剂-1是一种有效的、竞争性的双重位点（ATP和肽结合）Src激酶抑制剂。Src抑制剂-1是Src激酶抑制的“金标准”之一。研究已经显示通过Src-I1与PP1或PP2一起使用可抑制Src家族激酶。Src抑制剂-1是酪氨酸激酶Src家族的选择性竞争性抑制剂（分别对于Src和Lck的IC50为44nM和88nM）。Src抑制剂-1可以更高的浓度抑制VEGFR2和c-fms酪氨酸激酶（IC50分别为0.32 μM和30 μM）。
除Src激酶外，一些Src抑制剂也可抑制Abl激酶、Lck、Csk和Yes蛋白的活性，因此研究人员正在探索将其作为可行的抗癌药物的可能性。
特點和優勢
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
其他客户在看
Diane H Boschelli et al.
Journal of medicinal chemistry, 47(7), 1599-1601 (2004-03-19)
We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.
Lei Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 57, 72-83 (2019-01-23)
Periploca forrestii(PF) is mainly utilized for treatment of arthritis and traumatic injury historically. We had previously demonstrated that a fraction rich in cardiotonic steroids isolated from PF had the potential to facilitate wound healing. However, the exact material basis and
Devin McGee et al.
PloS one, 12(11), e0188645-e0188645 (2017-12-01)
Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using
Scott T Wood et al.
Arthritis & rheumatology (Hoboken, N.J.), 68(1), 117-126 (2015-09-01)
Oxidative posttranslational modifications of intracellular proteins can potentially regulate signaling pathways relevant to cartilage destruction in arthritis. In this study, oxidation of cysteine residues to form sulfenic acid (S-sulfenylation) was examined in osteoarthritic (OA) chondrocytes and investigated in normal chondrocytes
Changli Wei et al.
The Journal of clinical investigation, 129(5), 1946-1959 (2019-02-08)
Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived circulating signaling molecule that has been implicated in chronic kidney disease, such as focal segmental glomerulosclerosis (FSGS). Typically, native uPAR (isoform 1) translates to a 3-domain protein capable of binding and
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