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Merck

P0040

Sigma-Aldrich

PP1

≥98% (HPLC)

别名:

4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine

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About This Item

经验公式(希尔记法):
C16H19N5
分子量:
281.36
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

DMSO: >20 mg/mL

儲存溫度

room temp

SMILES 字串

Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C

InChI

1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)

InChI 密鑰

ZVPDNRVYHLRXLX-UHFFFAOYSA-N

應用

PP1已用作:
  • 肉瘤(Src)家族激酶(SFK)的抑制剂,如造血细胞激酶(hck)和fyn
  • 在海马神经元培养中选择Src酪氨酸激酶抑制剂以测试其对神经突生长的影响
  • Src激酶阻滞剂,以测试对溴莫尼定(BMD)诱导的细胞外信号激活激酶(ERK1/2)磷酸化的影响

生化/生理作用

PP1是一种吡唑嘧啶化合物,作为三磷酸腺苷(ATP)结合的竞争性抑制剂。它还能抑制蛋白酪氨酸激酶(PTK6),可用于PTK6阳性乳腺癌恶性肿瘤的治疗管理。
PP1 是一种有效的选择性 Src 家族蛋白酪氨酸激酶抑制剂。

特點和優勢

这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于其他研究领域中关于生物活性小分子的消息。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Qian Wang et al.
Environmental science and pollution research international, 26(21), 21774-21783 (2019-05-28)
Due to variable amino acid residues at positions 2 and 4, microcystins (MCs) had diversified variants with different toxicities. To evaluate the discrepant toxicity, the inhibition effects of five typical MC variants (with the changed amino acid residues at position
Katyayni Vinnakota et al.
Journal of cellular physiology, 232(12), 3468-3480 (2017-01-18)
The inflammatory milieu plays an important role in colon cancer development and progression. Previously, we have shown that tumor-associated macrophages (TAMs), an important component of the tumor microenvironment, are enriched in tumors compared with normal tissue and confer a poorer
Shunyu Gao et al.
General and comparative endocrinology, 240, 46-60 (2016-10-23)
Neuropeptide Y (NPY) receptors and its ligands, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are suggested to regulate many physiological processes including food intake in birds. However, our knowledge regarding this avian NPY system remains rather limited. Here, we
Xiaotong Zhu et al.
International journal for parasitology, 49(9), 685-695 (2019-06-17)
Sexual development in malaria parasites involves multiple signal transduction pathways mediated by reversible protein phosphorylation. Here, we functionally characterised a protein phosphatase, Ser/Thr protein phosphatase 5 (PbPP5), during sexual development of the rodent malaria parasite Plasmodium berghei. The recombinant protein
Jun Mori et al.
Blood, 131(10), 1122-1144 (2018-01-06)
Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like protein tyrosine-phosphatase CD148 in mice results in

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