推荐产品
物種活性
human
包裝
kit of 96 wells (12 strips x 8 wells)
技術
ELISA: suitable
capture ELISA: suitable
輸入
sample type plasma
sample type cell culture supernatant(s)
sample type urine
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/mL
standard curve range: 16.46-4000 pg/mL
檢測方法
colorimetric
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... AREG(374)
一般說明
The Human Amphiregulin (AR) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human AR in serum, plasma, cell culture supernatants and urine.
The AREG (amphiregulin) gene codes for a shedding ectodomain, derived from a transmembrane precursor of 252 amino acids. The encoded protein is released into blood or cellular vicinity through autocrine and paracrine. Areg is predominantly expressed in epithelial, mesenchymal cells and also by active immune cells. The AREG gene is mapped to human chromosome 4q13.3.
The AREG (amphiregulin) gene codes for a shedding ectodomain, derived from a transmembrane precursor of 252 amino acids. The encoded protein is released into blood or cellular vicinity through autocrine and paracrine. Areg is predominantly expressed in epithelial, mesenchymal cells and also by active immune cells. The AREG gene is mapped to human chromosome 4q13.3.
免疫原
Recombinant Human Amphiregulin
應用
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human Amphiregulin ELISA Kit has been used to estimate the plasma concentration of amphiregulin by ELISA.
Human Amphiregulin ELISA Kit has been used to estimate the plasma concentration of amphiregulin by ELISA.
生化／生理作用
Areg (amphiregulin) stimulates growth-signaling pathways via EGF (epidermal growth factor) receptors. Areg participates in the organogenesis of mammary gland. It is regarded as a pro-oncogenic factor and contributes to tumor progression. Upregulation of the AREG gene is observed in cancer and resists chemotherapy. AREG reduces E-cadherin expression in order to promote invasion and progression of ovarian cancer.
其他說明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
试剂盒组分也可单独购买
产品编号
说明
化学品安全说明书
訊號詞
Warning
危險聲明
防範說明
危險分類
Met. Corr. 1
儲存類別代碼
8A - Combustible corrosive hazardous materials
Correlation between Trop2 and amphiregulin coexpression and overall survival in gastric cancer.
Zhao W, et al.
Cancer Medicine, 6(5), 994-1001 (2017)
Predictive blood plasma biomarkers for EGFR inhibitor-induced skin rash.
Hichert V, et al.
Oncotarget, 8(21), 35193-35193 (2017)
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
Cheng J C, et al.
Oncotarget, 7(49), 81645-81645 (2016)
Abnormal amphiregulin expression correlates with gastric cancer prognosis.
Wang B, et al.
Oncotarget, 7(47), 76684-76684 (2016)
Masaru Karakawa et al.
Journal of cellular physiology, 229(12), 1935-1945 (2014-04-09)
The cutaneous T cell-attracting chemokine (CTACK)/CCL27 is indispensable in skin inflammation. CTACK/CCL27 is exclusively produced by epidermal keratinocytes to attract CCR10-expressing T lymphocytes to the skin. We investigated the mechanism of CTACK/CCL27 production from normal human epidermal keratinocytes (NHEKs) by
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