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R9156

Sigma-Aldrich

Raltitrexed

≥98% (HPLC), solid

别名:

L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl), ICI-D-1694, ZD-1694

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About This Item

经验公式（希尔记法）:
C21H22N4O6S
CAS号:
112887-68-0
分子量:
458.49
分類程式碼代碼:
12352200
PubChem物質ID:
329824044
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

顏色

off-white to light yellow

溶解度

H2O: ≥10 mg/mL
DMSO: ≥40 mg/mL

起源

AstraZeneca

儲存溫度

2-8°C

SMILES 字串

O=C1NC(C)=NC2=C1C=C(CN(C3=CC=C(C(N[C@H](CCC(O)=O)C(O)=O)=O)S3)C)C=C2

生化／生理作用

Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

特點和優勢

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險聲明

H300,H360

危險分類

Acute Tox. 2 Oral - Repr. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书(COA)

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叶酸 ≥97%

Sigma-Aldrich

F7876

叶酸

甲氨蝶呤 水合物 powder, BioReagent, suitable for cell culture, ≥98% (HPLC)

Sigma-Aldrich

M8407

甲氨蝶呤 水合物

Helena Almqvist et al.
Nature communications, 7, 11040-11040 (2016-03-25)
Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. We report here the first compound library screen based on

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