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重組細胞
expressed in E. coli
品質等級
形狀
liquid
分子量
52 kDa by SDS-PAGE
技術
ELISA: suitable
UniProt登錄號
儲存溫度
−70°C
基因資訊
human ... TRIM21(6737)
一般說明
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. It is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis. Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
應用
RO-52 (SSA) human has been used:
- as a component of the autoantigen array
- to immobilise protein on the self-assembly monolayer
- in enzyme-linked immunosorbent assays (ELISAs)
生化／生理作用
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
外觀
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Anti-ro52 antibodies and interstitial lung disease in connective tissue diseases excluding scleroderma
Ferreira J, et al.
ISRN rheumatology, 2012, 415-421 (2012)
Autoantigen TRIM21/Ro52 as a possible target for treatment of systemic lupus erythematosus
Yoshimi R, et al.
International journal of rheumatology, 2012, 6277-6285 (2012)
Electronic Structure Calculation and Superconductivity in lambda-(BETS) 2GaCl4
Aizawa H, et al.
Journal of the Physical Society of Japan, 87(9), 093701-093701 (2018)
Serological epitope profile of anti-Ro52-positive patients with systemic autoimmune rheumatic diseases
Infantino M, et al.
Arthritis Research & Therapy, 17(1), 365-365 (2015)
Mapping molecular binding by means of conformational dynamics measurements
do Nascimento NM, et al.
Royal Society of Chemistry Advances, 8(2), 867-876 (2018)
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