推荐产品
品質等級
化驗
>96% (HPLC)
形狀
solid
儲存條件
desiccated
顏色
white to tan
溶解度
H2O: >5 mg/mL at ≤60 °C
運輸包裝
wet ice
儲存溫度
2-8°C
SMILES 字串
O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3
InChI
1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1
InChI 密鑰
SZPHEVAYLIVGRC-BAMQSBMESA-N
應用
Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
- to study its effects on the surge of dopamine in the cortex of mice brain
- to study its anti-immobility effects on the behavior of mice
- to analyze its effects on the probabilistic reversal learning task in rodents
生化／生理作用
Reboxetine exhibits anti-depressant activity.
Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.
特點和優勢
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
S Kasper et al.
Expert opinion on pharmacotherapy, 1(4), 771-782 (2001-03-16)
Several treatment approaches are available for treatment of depression. However, reboxetine is the first selective noradrenaline re-uptake inhibitor. Whereas formerly only noradrenaline re-uptake inhibitors with a mixed mechanism of action were available. These included action not only at noradrenergic, but
Hagar Gelbard-Sagiv et al.
Current biology : CB, 28(14), 2239-2249 (2018-07-10)
An identical sensory stimulus may or may not be incorporated into perceptual experience, depending on the behavioral and cognitive state of the organism. What determines whether a sensory stimulus will be perceived? While different behavioral and cognitive states may share
Charlotte J W Connell et al.
Medicine and science in sports and exercise, 49(9), 1778-1788 (2017-04-30)
Fatigue-induced impairments in the control of eye movements are detectable via reduced eye movement velocity after a bout of prolonged, strenuous exercise. Slower eye movements caused by neural fatigue within the oculomotor system can be prevented by caffeine, and the
Kristine Chobanyan-Jürgens et al.
Scientific reports, 8(1), 7748-7748 (2018-05-19)
Clinical trials and studies with ivabradine implicate cardiac pacemaker channels (HCN4) in the pathogenesis of atrial arrhythmias. Because acute changes in cardiac autonomic tone predispose to atrial arrhythmias, we studied humans in whom profound cardiac sympathetic activation was rapidly relieved
J M Kent
Lancet (London, England), 355(9207), 911-918 (2001-02-07)
A major goal of antidepressant development is to improve on preceding drug classes with agents with greater specificity (and therefore fewer unwanted side-effects) and with more rapid onset of antidepressant action. To this end, four antidepressants with significantly distinct pharmacological
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