5.04120

Reboxetine Mesylate

• 别名: Reboxetine Mesylate, (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine methanesulfonate, Edronax, Vestra
• 经验公式（希尔记法）: C₁₉H₂₃NO₃ · xCH₄O₃S
• CAS号: 98769-84-7
• 分子量: 313.39 (free base basis)
• MDL號碼: MFCD18711354
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥99% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 顏色: white
• 溶解度: water: 20 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: [S](=O)(=O)(O)C.N1C[C@@H](OCC1)[C@H](Oc3c(cccc3)OCC)c2ccccc2
• InChI: 1S/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1
• InChI 密鑰: CGTZMJIMMUNLQD-STYNFMPRSA-N

说明

一般說明

A potent and selective inhibitor of noradrenalin uptake (K_i values are 1.1, 129 and >10000 nM for rat NET, SERT and DAT, respectively). Displays >1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

生化／生理作用

Primary Target
Noradrenalin transporter

Target K_i: 1.1, 129 and >10000 nM for rat NET, SERT and DAT respectively

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze 9-20°C. Stock solutions are stable for up to 3 months at -20°C.

其他說明

Sacchetti, G., et al. 1999. Br. J. Pharmacol.128, 1332.

Wong, E., et al. 2000. Biol. Psychiatry.47, 818.
Millan, M., et al. 2001. J. Pharmacol. Exp. Ther.298,565.
Owen, J., et al. 2003 Neurosci. Lett.348, 171.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07,GHS08
• 訊號詞: Danger
• 危險聲明: H302 - H360D
• 防範說明: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• 危險分類: Acute Tox. 4 Oral - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable