所有图片(1)
About This Item
经验公式（希尔记法）:
C21H27N7O
CAS号:
分子量:
393.49
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
化驗
≥98% (HPLC)
形狀
solid
溶解度
DMSO: soluble 7 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
C1CCC(CC1)Nc2nc(Nc3ccc(cc3)N4CCOCC4)nc5nc[nH]c25
InChI
1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
InChI 密鑰
ZFLJHSQHILSNCM-UHFFFAOYSA-N
基因資訊
human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)
rat ... Adora3(25370)
應用
逆转素已被用作单极纺锤体 1 (Mps1) 激酶抑制剂或有丝分裂纺锤体装配检查点 (SAC) 抑制剂：
- 研究康普瑞汀 A4 (CA4) 介导的细胞毒性是否需要有丝分裂阻滞
- 研究 SAC 活化对 eb 病毒 (EBV) 复制的贡献
- 诱导染色体错分
生化／生理作用
逆转素最早被描述为一种合成的取代嘌呤，具有去分化剂的活性；它被证明可以诱导分化的谱系定向细胞成为多潜能间充质干细胞 (MSCs)。还显示出具有强效、选择性人 a 3 腺苷受体拮抗剂的活性（K i 值为 0.66μl）。ATP-竞争性 Aurora 激酶抑制剂，Mps1 激酶抑制剂。此外，研究表明，逆转素是一种抗癌药物，可抑制多种癌细胞的生长并诱导其死亡。
儲存和穩定性
根据其他来源，在DMSO中储存的逆转溶液只能在短期内稳定冷藏。对于长期储存，等分试样应在-20°C下稳定保存最长2年。不建议溶液在常温下存放。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Krishna K Sarangapani et al.
The Journal of cell biology, 220(12) (2021-10-15)
Dividing cells detect and correct erroneous kinetochore-microtubule attachments during mitosis, thereby avoiding chromosome missegregation. The Aurora B kinase phosphorylates microtubule-binding elements specifically at incorrectly attached kinetochores, promoting their release and providing another chance for proper attachments to form. However, growing
G N Subramanian et al.
Molecular human reproduction, 27(2) (2020-12-19)
Premature loss of ovarian activity before 40 years of age is known as primary ovarian insufficiency (POI) and occurs in ∼1% of women. A more subtle decline in ovarian activity, known as premature ovarian ageing (POA), occurs in ∼10% of women.
Chromosome mis-segregation generates cell-cycle-arrested cells with complex karyotypes that are eliminated by the immune system
Santaguida S, et al.
Developmental Cell, 41(6), 638-651 (2017)
Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest.
Tarade D, et al.
PLoS ONE, 12(3), e0171806-e0171806 (2017)
Federica Schiavoni et al.
Nature communications, 13(1), 1731-1731 (2022-04-03)
Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context dependent. The BRG1
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门