R0775

RANK/Fc Chimera from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• 别名: Osteoclast differentiation receptor, ODFR, Receptor activator of NF-κB
• MDL號碼: MFCD03703131
• 分類程式碼代碼: 51111800
• NACRES: NA.32

属性

• 生物源: mouse
• 品質等級: 200
• 重組細胞: expressed in NSO cells
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized powder
• 效力: 10.12 μg/mL EC₅₀
• 分子量: 60 kDa
• 包裝: pkg of 1 mg
• 儲存條件: avoid repeated freeze/thaw cycles
• 技術: cell culture | mammalian: suitable
• 雜質: endotoxin, tested
• UniProt登錄號: O35305
• 儲存溫度: −20°C
• 基因資訊: mouse ... Tnfrsf11a(21934)

说明

應用

RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF-ΚB and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis.

生化／生理作用

TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

分析報告

The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable