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Merck
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主要文件

R0655

Sigma-Aldrich

Anti-Ribosomal Protein L26 (N-terminal) 兔抗

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-RPL26

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 17 kDa

物種活性

mouse, human, rat

濃度

~1 mg/mL

技術

immunoprecipitation (IP): 5-10 μg using HEK-293T cell lysates
indirect immunofluorescence: 5-10 μg/mL using paraformaldehye-fixed HeLa cells
western blot: 0.5-1 μg/mL using HEK-293T cell extracts

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... RPL26(6154)
mouse ... Rpl26(19941)
rat ... Rpl26(287417)

一般說明

RPL26 (ribosomal protein L26) is located on chromosome 17. It codes for a 145-amino-acid long protein and has four exons. It is present on the large ribosomal subunit.
Ribosomal protein L26 is one of the large ribosomal subunit proteins.

特異性

Anti-Ribosomal Protein L26 (N-terminal) specificallyrecognizes human Ribosomal Protein L26.

免疫原

synthetic peptide corresponding to amino acids 1-17 of human ribosomal protein L26, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, rat, and mouse.

應用

Anti-Ribosomal Protein L26 (N-terminal) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunostaining
  • immunofluorescence
  • coimmunoprecipitation analysis

生化/生理作用

RPL26 (ribosomal protein L26) regulates the expression of p73. It plays an important role in translation and stability of ribosomes. RPL26 frameshift mutation can cause several physical abnormalities.
Ribosomal proteins are implicated in mRNA recognition, tRNA recognition and decoding and nuclear export. It was shown together with nucleolin to bind to the 5′ untranslated region of p53 mRNA and to control p53 translation and induction after DNA damage.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Molecular cloning of ribosomal protein L26 (RPL26) cDNA from Ailuropoda melanoleuca and its potential value in phylogenetic study
Hou W, et al.
Biochemical Systematics and Ecology, 36 (2008)
The social life of ribosomal proteins
Brodersen DE and Nissen P
The FEBS journal, 272(9), 2098-2108 (2005)
Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-? Peptide Generation In Vivo
Serrano-Pozo A, et al.
PLoS ONE, 12(1) (2017)
p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability
Zhang M, et al.
Oncotarget, 7(48), 78255-78268 (2016)
Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
Ofir-RY, et al.
Molecular Cell, 32(2), 180-189 (2008)

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