推荐产品
product name
UK-5099, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
顏色
yellow to tan
溶解度
DMSO: >20 mg/mL
儲存溫度
2-8°C
SMILES 字串
OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N
InChI
1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChI 密鑰
BIZNHCWFGNKBBZ-JLHYYAGUSA-N
應用
UK-5099已用于：
- 在用于前列腺癌细胞系培养的Roswell公园纪念研究所（RPMI）1640培养基中用作线粒体丙酮酸阻滞剂，以减少丙酮酸向线粒体的运输
- 二甲基亚砜（DMSO）的储备液中， 以研究抑制丙酮酸转运入线粒体对脂多糖激活的巨噬细胞促炎反应的影响
- 局部处理，以用于研究其对实验小鼠毛发周期诱导的作用
生化／生理作用
UK-5099可诱导产生乳酸。
UK-5099是线粒体丙酮酸转运蛋白的有效抑制剂。n大鼠心脏线粒体，UK-5099可抑制丙酮酸依赖性O2消耗，IC50 为50 nM。
特點和優勢
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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