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Merck

PZ0143

Sigma-Aldrich

PF-4708671

≥98% (HPLC)

别名:

2-((4-(5-乙基嘧啶-4-基)哌嗪-1-基)甲基)-5-(三氟甲基)-1H-苯并 [d] 咪唑

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About This Item

经验公式(希尔记法):
C19H21F3N6
分子量:
390.41
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

off-white

溶解度

DMSO: ≥20 mg/mL

儲存溫度

room temp

SMILES 字串

CCC(C=NC=N1)=C1N2CCN(CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)CC2

InChI

1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)

InChI 密鑰

FBLPQCAQRNSVHB-UHFFFAOYSA-N

基因資訊

生化/生理作用

PF-4708671 是一种选择性 p70 核糖体 S6 激酶 (S6K1) 抑制剂。PF-4708671 抑制 S6K1,Ki 为 20 nM,IC 50 为 160 nM,而对密切相关的 RSK 和 MSK 激酶无影响。

特點和優勢

《受体分类和信号转导》手册的 PKB/Akt 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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International journal of stem cells, 14(3), 341-350 (2021-04-29)
Approximately 15% of couples suffer from infertility worldwide, and male factors contribute to about 30% of total sterility cases. However, there is little progress in treatments due to the obscured understanding of underlying mechanisms. Recently microRNAs have emerged as a
Erika Ishihara et al.
Genes to cells : devoted to molecular & cellular mechanisms, 25(3), 197-214 (2020-01-29)
Cell competition is a biological process by which unfit cells are eliminated from "cell society." We previously showed that cultured mammalian epithelial Madin-Darby canine kidney (MDCK) cells expressing constitutively active YAP were eliminated by apical extrusion when surrounded by "normal"

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