PZ0111

PD-407824

≥98% (HPLC)

• 别名: 9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
• 经验公式（希尔记法）: C₂₀H₁₂N₂O₃
• CAS号: 622864-54-4
• 分子量: 328.32
• MDL號碼: MFCD09753286
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329823703
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: yellow to orange
• 溶解度: DMSO: >10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Oc1ccc2[nH]c3cc(-c4ccccc4)c5C(=O)NC(=O)c5c3c2c1
• InChI: 1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25)
• InChI 密鑰: IAUZTOZLTFSMIE-UHFFFAOYSA-N

说明

應用

PD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine.

生化／生理作用

PD-407824 is a Wee1/Chk1 inhibitor.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable