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E3763

Sigma-Aldrich

乙氧基试卤灵

≥98% (TLC), powder

别名:

7-乙氧基-3H-吩恶嗪-3-酮, O 7 -乙基试卤灵, 乙氧基试卤灵

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About This Item

经验公式（希尔记法）:
C14H11NO3
CAS号:
5725-91-7
分子量:
241.24
Beilstein:
225973
MDL號碼:
MFCD00037661
分類程式碼代碼:
12161501
PubChem物質ID:
24894527
NACRES:
NA.47

品質等級

200

化驗

≥98% (TLC)

形狀

powder

儲存條件

(Tightly closed. Dry)

技術

activity assay: suitable

顏色

orange to red

mp

223-225 °C (lit.)

溶解度

chloroform: 9.80-10.20 mg/mL, clear, orange

適合性

suitable for fluorescence

儲存溫度

−20°C

SMILES 字串

CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F

InChI

1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3

InChI 密鑰

ZOSYTBPPLWBBKM-UHFFFAOYSA-N

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一般說明

试卤灵被用作不同细胞色素 P (CYP) 亚型的标记物或底物。试卤灵乙醚是 3-甲基胆蒽处理动物的微粒体代谢的首选试卤灵乙醚。
试卤灵（Resorufin）是刃天青的还原产物，也称为阿尔玛蓝（Alamar Blu）。它在较长的波长下发射荧光，并且其羟基可进行灵活的修饰。

适用研究领域：细胞信号传导

應用

试卤灵乙醚适用于研究细胞色素 P450 同工酶 1A1 和 1A2 的脱烷基活性，其中芳基烷基和烷基异硫氰酸盐及其谷胱甘肽、半胱氨酸和 A′-乙酰半胱氨酸结合物用作抑制剂。适合于研究细胞色素 P450 活性 (CYP1A1) 的乙氧基试卤灵-O-脱乙基酶 (EROD) 活性。

基底

细胞色素 P450 连接酶 CXPIA1/2 的荧光底物

基底

产品编号
说明
价格

M1544

Resorufin methyl ether

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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A resorufin derivative as a fluorogenic indicator for cell viability
Ishiyama M, et al.
Analytical Sciences, 15(10), 1025-1028 (1999)
V Villa-Cruz et al.
Chemosphere, 74(9), 1145-1151 (2009-01-16)
Tilapia fish (Oreochromis niloticus) were fed with enriched diets containing broccoli and its phytochemical sulforaphane over 30 d. The levels of cytochrome P450, superoxide dismutase, catalase, lipid peroxidation and glutathione-S-transferase activities were measured. Basal value of cytochrome P450 activity was
Reduction of resazurin to resorufin catalyzed by gold nanoparticles: dramatic reaction acceleration by laser or LED plasmon excitation
Alejo CJ, et al.
Catalysis Science & Technology, 1(8), 1506-1511 (2011)
C C Conaway et al.
Carcinogenesis, 17(11), 2423-2427 (1996-11-01)
A series of arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and N-acetylcysteine conjugates were used to study their inhibitory activity toward the dealkylation of ethoxyresorufin (EROD), pentoxyresorufin (PROD), and methoxyresorufin (MROD) in liver microsomes obtained from the 3-methylcholanthrene or
Thomas K H Chang et al.
Journal of pineal research, 48(1), 55-64 (2009-11-19)
Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites. The present study tested the hypothesis that melatonin
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Phase I Drug Metabolism

Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation.

Phase I Drug Metabolism

Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation.

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