PZ0015
Trovafloxacin mesylate
>98% (HPLC), powder, Pannexin 1 inhibitor
别名:
(1α,5α,6α)-7-(6-Amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid methanesulfonate, CP-99219-27, Trovafloxacin methanesulfonate
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所有图片(1)
About This Item
经验公式（希尔记法）:
C20H15F3N4O3 · CH3SO3H
CAS号:
分子量:
512.46
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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产品名称
Trovafloxacin mesylate, >98% (HPLC)
化驗
>98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: >10 mg/mL
儲存溫度
room temp
SMILES 字串
CS(O)(=O)=O.NC1C2CN(CC12)c3nc4N(C=C(C(O)=O)C(=O)c4cc3F)c5ccc(F)cc5F
InChI
1S/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16+;
InChI 密鑰
DYNZICQDCVYXFW-AHZSKCOESA-N
應用
Trovafloxacin mesylate has been used as a test compound in toxicity assay to assess its toxicity in 2D hepatocyte cultures. It has also been used to manipulate the mechanism of apoptotic cell disassembly during apoptosis.
生化／生理作用
Trovafloxacin mesylate acts as a pannexin1 (Panx1) inhibitor.
Trovafloxacin mesylate is a broad spectrum antibiotic.
Trovafloxacin mesylate is a broad spectrum antibiotic. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, enzymes essential in the repliction, transcription, and repair of bacterial DNA.
訊號詞
Danger
危險聲明
危險分類
Repr. 2 - Skin Corr. 1B
儲存類別代碼
8A - Combustible corrosive hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Determining the contents and cell origins of apoptotic bodies by flow cytometry
Jiang L, et al.
Scientific reports, 7(1), 14444-14444 (2017)
Bioprinted 3D primary liver tissues allow assessment of organ-level response to clinical drug induced toxicity in vitro
Nguyen DG, et al.
PLoS ONE, 11(7), e0158674-e0158674 (2016)
Akira Nakajima et al.
Cell biology and toxicology, 34(1), 65-77 (2017-03-13)
Fluoroquinolones and propionic acid derivatives are widely used antibacterials and non-steroidal anti-inflammatory drugs, respectively, which have been reported to frequently trigger drug hypersensitivity reactions. Such reactions are induced by inflammatory mediators such as cytokines and chemokines. The present study investigated
Jieyu Xu et al.
Toxicology in vitro : an international journal published in association with BIBRA, 48, 286-301 (2018-02-07)
Immortalized liver cells have been used for evaluating the toxicity of compounds; however, excessive glutathione is considered to lessen cytotoxicity. In this study, we compared the effects of glutathione depletion on cytotoxicities of drugs using HepaRG and HepG2 cells, which
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