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Merck
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主要文件

PLA0248

Sigma-Aldrich

Rabbit anti-BAP1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

别名:

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BRCA1-associated protein 1, HUCEP-13, KIAA0272, UCHL2, cerebral protein 6, cerebral protein-13, hucep-6, ubiquitin carboxy-terminal hydrolase

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity purified immunoglobulin

抗體產品種類

primary antibodies

等級

Powered by Bethyl Laboratories, Inc.

物種活性

human

技術

immunoprecipitation (IP): 5-10 μg/mg
western blot: 1:2,000- 1:10,000

登錄號

NP_004647.1

UniProt登錄號

運輸包裝

wet ice

儲存溫度

2-8°C

目標翻譯後修改

unmodified

基因資訊

rabbit ... BAP1(8314)

免疫原

The epitope recognized by PLA0248 maps to a region between residue 679 and 729 of human BRCA1-associated protein 1 using the numbering given in entry NP_004647.1 (GeneID 8314).

外觀

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

其他說明

BRCA1-associated protein 1 (BAP1) functions as a C-terminal ubiquitin hydrolase and may be involved in the transduction of signals in the BRCA1 pathway. BAP1 is also implicated to be a tumor suppressor as defects in BAP1 are found in non-small cell lung cancer cell lines.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Marta Betti et al.
Genes, chromosomes & cancer, 54(1), 51-62 (2014-09-19)
Inherited loss-of-function mutations in the BAP1 oncosuppressor gene are responsible for an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and keratinocytic melanoma, and other malignancies. Germline mutations that were inherited in an autosomal dominant fashion were identified in
Han-Sae Lee et al.
Nature communications, 5, 5128-5128 (2014-10-07)
The INO80 chromatin-remodelling complex has been implicated in DNA replication during stress in yeast. However, its role in normal DNA replication and its underlying mechanisms remain unclear. Here, we show that INO80 binds to replication forks and promotes fork progression

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