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品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white to beige
溶解度
DMSO: soluble >10 mg/mL
H2O: insoluble
SMILES 字串
C1Sc2ccccc2-c3[nH]c4ccccc4c13
InChI
1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
InChI 密鑰
ZGOOPZVQMLHPFM-UHFFFAOYSA-N
基因資訊
human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)
應用
PD 146176已被用于研究其对脂肪组织中离体白细胞三烯B4（LTB4）和脂氧素A4（LXA4）分泌的影响。
生化／生理作用
PD 146176通过抑制5-脂氧合酶1（15-LOX-1）来阻断神经保护素D1（NPD1）和类花生酸的合成。
15-脂氧合酶抑制剂
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
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Despite the importance of radiation therapy, there are few radiation-related markers available for use in clinical practice. A larger catalog of such biomarkers is required to help clinicians decide when radiotherapy should be replaced with a patient-specific treatment. Arachidonate 15-lipoxygenase
Manuela Schneider et al.
Neoplasia (New York, N.Y.), 12(3), 254-263 (2010-03-18)
The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogenesis. Therefore, we hypothesized a putative regulatory role of GPx4 during tumor progression and created
Haider H Dar et al.
The Journal of clinical investigation, 128(10), 4639-4653 (2018-09-11)
Ferroptosis is a death program executed via selective oxidation of arachidonic acid-phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, ferroptosis has been pathogenically associated with brain, kidney, and liver injury/diseases. We discovered that a prokaryotic bacterium, Pseudomonas aeruginosa, that
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