推荐产品
product name
DL-缬氨酸,
化驗
≥98% (HPLC)
形狀
powder
技術
HPLC: suitable
顏色
white
mp
>300 °C
SMILES 字串
CCCC(N)C(O)=O
InChI
1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
InChI 密鑰
SNDPXSYFESPGGJ-UHFFFAOYSA-N
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一般說明
正缬氨酸(Norvaline)是一种非蛋白质α-氨基酸，又名DL-α-氨基戊酸。它产自大肠杆菌等革兰氏阴性菌，也是枯草芽孢杆菌所产抗真菌肽的组分。
應用
DL-正缬氨酸作为内部标准品，已用于：
- 气相色谱-质谱法(GC-MS)分析哺乳动物培养细胞的代谢物
- 将半胱氨酸和胱氨酸转化为Cys MPA(S-2-羧乙基硫代-L-半胱氨酸)，并采用高效液相色谱(HPLC)分析仪进行定量分析
- 液相色谱法分析卵母细胞样本中的游离氨基酸
生化／生理作用
DL-戊氨酸是一种神经递质。
正缬氨酸介导促进一氧化氮生成的生理和病理生理过程。可用于治疗阿尔茨海默病，并可有效抵抗大鼠模型的代谢综合征。正缬氨酸冷却到190K以下后会发生相变，因此可用于分子机器。DL-正缬氨酸可作为含线性侧链的脂肪族α-氨基酸的多态性和分子动力学研究的原型，影响蛋白质的活性、稳定性和侧链堆积。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Jens Neu et al.
Physical chemistry chemical physics : PCCP, 20(1), 276-283 (2017-12-06)
dl-Norvaline is a molecular crystal at room temperature and it undergoes a phase transition when cooled below 190 K. This phase transition is believed to be Martensitic, thus making it of particular interest for molecular machines. In this paper we
Esther W Lim et al.
Methods in molecular biology (Clifton, N.J.), 2088, 51-71 (2020-01-02)
Oxidation-reduction (redox) reactions are ubiquitous in biology and typically occur in specific subcellular compartments. In cells, the electron transfer between molecules and organelles is commonly facilitated by pyridine nucleotides such as nicotinamide adenine dinucleotide phosphate (NADPH) and nicotinamide adenine dinucleotide
W Sosroseno et al.
Oral microbiology and immunology, 21(3), 145-150 (2006-04-22)
The aim of the present study was to determine whether or not lipopolysaccharide from Actinobacillus actinomycetemcomitans could stimulate arginase activity in a murine macrophage cell line (RAW264.7 cells). RAW264.7 cells were treated with A. actinomycetemcomitans-lipopolysaccharide or lipopolysaccharide from Escherichia coli
Carl Henrik Görbitz
The journal of physical chemistry. B, 115(10), 2447-2453 (2011-02-22)
The amino acid DL-norvaline undergoes two solid-solid phase transitions between room temperature and -180 °C. Single-crystal X-ray diffraction studies show that the first of these transitions, taking place around -80 °C, is completely reversible with respect to crystal quality, whereas
Ramasamy Sankaranarayanan et al.
Journal of molecular biology, 375(4), 1052-1063 (2007-12-08)
Mycobacterium tuberculosis ornithine carbamoyltransferase (Mtb OTC) catalyzes the sixth step in arginine biosynthesis; it produces citrulline from carbamoyl phosphate (CP) and ornithine (ORN). Here, we report the crystal structures of Mtb OTC in orthorhombic (form I) and hexagonal (form II)
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