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Merck
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N5764

Sigma-Aldrich

乳酸链球菌肽 来源于乳酸乳球菌

potency: ≥900 IU/mg

别名:

Nisin A

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About This Item

经验公式（希尔记法）:
C143H230N42O37S7
CAS号:
1414-45-5
分子量:
3354.07
MDL號碼:
MFCD00131724
分類程式碼代碼:
51102829
PubChem物質ID:
24897751
NACRES:
NA.85

形狀

powder

品質等級

200

效力

≥900 IU/mg

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell membrane | interferes

儲存溫度

2-8°C

SMILES 字串

[H]N[C@@H]([C@@H](C)CC)C(=O)N\C(=C\C)C(=O)N[C@H]1CSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@H]2[C@H](C)SC[C@H](NC(=O)CNC(=O)[C@@H]3CCCN3C2=O)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]4[C@@H](C)SC[C@H](NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC4=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]5[C@H](C)SC[C@@H]6NC(=O)[C@@H](NC(=O)[C@H](C)NC5=O)[C@H](C)SC[C@H](NC(=O)[C@H](Cc7cnc[nH]7)NC6=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc8cnc[nH]8)C(=O)N[C@@H](C(C)C)C(=O)NC(=C)C(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C143H230N42O37S7/c1-24-69(11)105(148)135(213)162-82(27-4)118(196)174-94-58-225-59-95(175-123(201)89(48-67(7)8)169-115(193)74(16)158-138(216)107(70(12)25-2)180-132(94)210)133(211)184-112-79(21)229-61-96(160-104(190)56-152-134(212)100-38-34-44-185(100)142(112)220)128(206)164-84(36-29-32-42-145)120(198)182-109-76(18)226-60-97(161-103(189)55-151-117(195)85(39-45-223-22)165-122(200)88(47-66(5)6)168-113(191)72(14)156-102(188)54-153-136(109)214)129(207)171-92(51-101(147)187)125(203)166-86(40-46-224-23)119(197)163-83(35-28-31-41-144)121(199)183-110-77(19)228-63-99-130(208)170-90(49-80-52-149-64-154-80)124(202)176-98(62-227-78(20)111(141(219)177-99)181-116(194)75(17)159-140(110)218)131(209)173-93(57-186)127(205)179-108(71(13)26-3)139(217)172-91(50-81-53-150-65-155-81)126(204)178-106(68(9)10)137(215)157-73(15)114(192)167-87(143(221)222)37-30-33-43-146/h27,52-53,64-72,75-79,83-100,105-112,186H,15-16,24-26,28-51,54-63,144-146,148H2,1-14,17-23H3,(H2,147,187)(H,149,154)(H,150,155)(H,151,195)(H,152,212)(H,153,214)(H,156,188)(H,157,215)(H,158,216)(H,159,218)(H,160,190)(H,161,189)(H,162,213)(H,163,197)(H,164,206)(H,165,200)(H,166,203)(H,167,192)(H,168,191)(H,169,193)(H,170,208)(H,171,207)(H,172,217)(H,173,209)(H,174,196)(H,175,201)(H,176,202)(H,177,219)(H,178,204)(H,179,205)(H,180,210)(H,181,194)(H,182,198)(H,183,199)(H,184,211)(H,221,222)/b82-27+/t69-,70-,71-,72-,75-,76?,77?,78?,79?,83-,84+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,105-,106-,107-,108-,109+,110-,111-,112-/m0/s1

InChI 密鑰

NVNLLIYOARQCIX-ILAIHEEGSA-N

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相关类别

一般說明

化学结构：肽

應用

乳链菌肽是由乳酸乳球菌产生。它通常用作食品防腐剂。它也被用作细胞培养物中的选择性试剂，用于分离革兰氏阴性细菌、酵母和霉菌。乳链菌肽已在生物测定中用于研究翻译后修饰。
可用于在脂质II介导的细胞膜上形成目标孔。 可用于研究乳链菌肽-脂质II孔复合物的组装和稳定性。

生化／生理作用

乳酸链球菌素(Nisin)是具有杀菌作用的抗生素。 它可与细菌脂多糖的脂质A部分结合，并可导致高粱离体根来源皮层细胞的细胞膜穿孔。

作用机制：结合并干扰细胞质膜的通透性。
抗菌谱：革兰氏阴性和革兰氏阳性细菌（需要螯合剂，例如EDTA）。
乳链菌肽可结合细菌的细胞壁前体脂质成分并破坏细胞壁产生。乳链菌肽可改变细胞膜，并导致细胞质成分的泄漏和质子动力的破坏。

包裝

包装尺寸基于总固体重量

其他說明

保存于密闭容器内，置于干燥通风处。置于干燥处保存。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
098M4024V
099M4122V
089M4010V
069M4142V
019M4063V

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