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Merck
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主要文件

94261

Sigma-Aldrich

LL-37 (human) trifluoroacetate salt

≥95% (HPLC)

别名:

Human LL-37 amide Trifluoroacetate

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About This Item

经验公式(希尔记法):
C205H341N61O52 · xC2HF3O2
分子量:
4492.28 (free base basis)
分類程式碼代碼:
51101500
NACRES:
NA.85

品質等級

化驗

≥95% (HPLC)

形狀

powder (Lyophilisate)

顏色

colorless to white

溶解度

H2O: 1 mg/mL, clear, colorless

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
viruses

作用方式

cell membrane | interferes

儲存溫度

−20°C

Amino Acid Sequence

Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2

一般說明

Chemical structure: peptide

應用

LL-37 is used to study host defense mechanisms.

生化/生理作用

LL-37 is a muntifunctional host defense peptide with antibacterial, antiviral, and immunomodulating activities. It is the only cathelicidin-type peptide found in human. In addition to its antimicrobial activities, LL-37 has been found to regulate inflammation and neutralize lipopolysaccharides from Gram-negative bacteria.

包裝

1mg

其他說明

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Keep in a dry place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

Lot/Batch Number

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Ainhoa Revilla-Guarinos et al.
Applied and environmental microbiology, 86(14) (2020-05-18)
Bce-like systems mediate resistance against antimicrobial peptides in Firmicutes bacteria. Lactobacillus casei BL23 encodes an "orphan" ABC transporter that, based on homology to BceAB-like systems, was proposed to contribute to antimicrobial peptide resistance. A mutant lacking the permease subunit was

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